ABSTRACT:
As protein databases continue to grow in size, exhaustive
search methods that compare a query structure against every
database structure can no longer provide satisfactory performance.
Instead, the filter-and-refine paradigm offers an efficient
alternative to database search without compromising the accuracy of
the answers. In this paradigm, protein structures are represented
in an abstract form. During querying, based on the abstract
representations, the filtering phase prunes away dissimilar
structures quickly so that only a small collection of promising
structures are examined using a detailed structure alignment
technique in the refinement phase. In this talk, we will cover
an overview of the existing methods developed for the filtering phase,
and discuss the techniques that we have proposed for both the
filtering and the refinement phases.
ABOUT THE SPEAKER: Zeyar Aung received his Ph.D. in Computer Science from the National University of Singapore in 2006. He is currently a Research Fellow at the Institute for Infocomm Research, A*STAR, Singapore. His research interests include bioinformatics, cheminformatics, data mining, and database indexing and retrieval. He is a member of the Life Sciences Society.
ABOUT THE OLS BIOINFORMATICS FOR BIOLOGISTS SEMINAR SERIES:
The "virtuous cycle" of bioinformatics is revolutionizing the
biomedical sciences. Computational biologists produce analytical
and predictive bioinformatics tools that are increasingly used
to guide wet-lab research. In turn, the wet-lab biologist has
valuable experience, knowledge and data that can be used to
refine those bioinformatics tools.
The OLS Bioinformatics for Biologists seminar series will bring
together wet-lab and computational biologists from NUS, in an
informal setting, to promote collaborations and exchange of ideas.
Selected NUS computational biologists whose research has practical
application to wet-lab biology will present their work. Active
exchange of information during the seminar is encouraged.