NCBI Sequence Viewer PubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIMBooks Search PubMed Protein Nucleotide Structure Genome PMC OMIM Taxonomy Books ProbeSet 3D Domains UniSTS Domains SNP Journals UniGene PopSet for Limits Preview/Index History Clipboard Details Summary ASN.1 FASTA TinySeq XML GI List GenPept GBSeq XML Graphics XML defaultShow: 1 2 5 10 20 50 100 200 500 File Text Clipboard 1: NP_005695. protein tyrosine ...[gi:19743935] BLink, Domains, Links LOCUS PTPRU 1446 aa linear PRI 17-JAN-2003 DEFINITION protein tyrosine phosphatase, receptor type, U isoform 3 precursor; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron [Homo sapiens]. ACCESSION NP_005695 VERSION NP_005695.2 GI:19743935 DBSOURCE REFSEQ: accession NM_005704.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 1446) AUTHORS Wang,H., Lian,Z., Lerch,M.M., Chen,Z., Xie,W. and Ullrich,A. TITLE Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family JOURNAL Oncogene 12 (12), 2555-2562 (1996) MEDLINE 96293401 PUBMED 8700514 REFERENCE 2 (residues 1 to 1446) AUTHORS Crossland,S., Smith,P.D. and Crompton,M.R. TITLE Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase JOURNAL Biochem. J. 319 (Pt 1), 249-254 (1996) MEDLINE 97024447 PUBMED 8870675 REFERENCE 3 (residues 1 to 1446) AUTHORS Wang,B., Kishihara,K., Zhang,D., Hara,H. and Nomoto,K. TITLE Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells JOURNAL Biochem. Biophys. Res. Commun. 231 (1), 77-81 (1997) MEDLINE 97223402 PUBMED 9070223 REFERENCE 4 (residues 1 to 1446) AUTHORS Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S., White,R.A., Painter,C., Steinberger,A.A. and Avraham,H. TITLE Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells JOURNAL Gene 204 (1-2), 5-16 (1997) MEDLINE 98094249 PUBMED 9434160 REFERENCE 5 (residues 1 to 1446) AUTHORS Wang,B., Kishihara,K., Zhang,D., Sakamoto,T. and Nomoto,K. TITLE Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells JOURNAL Biochim. Biophys. Acta 1450 (3), 331-340 (1999) MEDLINE 99326162 PUBMED 10395944 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X97198.1 and X95712.1. On Mar 26, 2002 this sequence version replaced gi:5032003. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported. Transcript Variant: This variant (3) encodes the longest isoform (3). FEATURES Location/Qualifiers source 1..1446 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1p35.3-p35.1" Protein 1..1446 /product="protein tyrosine phosphatase, receptor type, U isoform 3 precursor" /note="protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron" sig_peptide 1..18 mat_peptide 19..1446 /product="protein tyrosine phosphatase, receptor type, U, isoform 3" Region 22..188 /region_name="Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)" /note="MAM" /db_xref="CDD:smart00137" Region 27..188 /region_name="MAM domain. An extracellular domain found in many receptors" /note="MAM" /db_xref="CDD:pfam00629" Region 196..283 /region_name="Immunoglobulin" /note="IG" /db_xref="CDD:smart00409" Region 286..357 /region_name="Fibronectin type 3 domain" /note="FN3" /db_xref="CDD:smart00060" Region 292..357 /region_name="Fibronectin type III domain" /note="fn3" /db_xref="CDD:pfam00041" Region 386..471 /region_name="Fibronectin type 3 domain" /note="FN3" /db_xref="CDD:smart00060" Region 484..576 /region_name="Fibronectin type 3 domain" /note="FN3" /db_xref="CDD:smart00060" Region 486..578 /region_name="Fibronectin type III domain" /note="fn3" /db_xref="CDD:pfam00041" Region 893..1146 /region_name="Protein tyrosine phosphatase, catalytic domain" /note="PTPc" /db_xref="CDD:smart00194" Region 896..971 /region_name="Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]" /note="AceE" /db_xref="CDD:COG2609" Region 918..1143 /region_name="Protein-tyrosine phosphatase" /note="Y_phosphatase" /db_xref="CDD:pfam00102" Region 925..1143 /region_name="Protein tyrosine phosphatase [Signal transduction mechanisms]" /note="PTP2" /db_xref="CDD:COG5599" Region 1042..1143 /region_name="Protein tyrosine phosphatase, catalytic domain motif" /note="PTPc_motif" /db_xref="CDD:smart00404" Region 1051..1138 /region_name="Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]" /note="CDC14" /db_xref="CDD:COG2453" Region 1153..1441 /region_name="Protein tyrosine phosphatase [Signal transduction mechanisms]" /note="PTP2" /db_xref="CDD:COG5599" Region 1175..1441 /region_name="Protein tyrosine phosphatase, catalytic domain" /note="PTPc" /db_xref="CDD:smart00194" Region 1203..1438 /region_name="Protein-tyrosine phosphatase" /note="Y_phosphatase" /db_xref="CDD:pfam00102" Region 1336..1438 /region_name="Protein tyrosine phosphatase, catalytic domain motif" /note="PTPc_motif" /db_xref="CDD:smart00404" CDS 1..1446 /gene="PTPRU" /coded_by="NM_005704.2:137..4477" /note="protein tyrosine phosphatase, receptor type, U" /db_xref="LocusID:10076" /db_xref="MIM:602454" ORIGIN 1 maraqalvla ltfqlcapet etpaagctfe easdpavpce ysqaqyddfq weqvrihpgt 61 rapadlphgs ylmvntsqha pgqrahvifq slsendthcv qfsyflysrd ghrpgtlgvy 121 vrvnggplgs avwnmtgshg rqwhqaelav stfwpneyqv lfealispdr rgymglddil 181 llsypcakap hfsrlgdvev nagqnasfqc maagraamrq rfllqrqsga lvpaagvrhi 241 shrrflatfp laavsraeqd lyrcvsqapr gagvsnfael ivkepptpia ppqllragpt 301 yliiqlntns iigdgpivrk eieyrmargp waevhavslq tyklwhldpd teyeisvllt 361 rpgdggtgrp gpplisrtkc aepmrapkgl afaeiqarql tlqweplgyn vtrchtytvs 421 lcyhytlgss hnqtirecvk teqgvsryti knllpyrnvh vrlvltnpeg rkegkevtfq 481 tdedvpsgia aesltftple dmiflkweep qepnglitqy eisyqsiess dpavnvpgpr 541 rtisklrnet yhvfsnlhpg ttylfsvrar tgkgfgqaal teittnisap sfdyadmpsp 601 lgesentitv llrpaqgrga pisvyqvive eerarrlrre rggqdcfpvp ltfeaalarg 661 lvhyfgaela asslpeampf tvgdnqtyrg fwnppleprk ayliyfqaas hlkgetrlnc 721 iriarkaack eskrplevsq rseemglilg icagglavli lllgaiivii rkgrdhyays 781 yypkpvnmtk atvnyrqekt hmmsavdrsf tdqstlqede rlglsfmdth gystrgdqrs 841 ggvteassll ggsprrpcgr kgspyhtgql hpavrvadll qhinqmktae gygfkqeyes 901 ffegwdatkk kdkvkgsrqe pmpaydrhrv klhpmlgdpn adyinanyid gyhrsnhfia 961 tqgpkpemvy dfwrmvwqeh cssivmitkl vevgrvkcsr ywpedsdtyg dikimlvkte 1021 tlaeyvvrtf alerrgysar hevrqfhfta wpehgvpyha tgllafirrv kastppdagp 1081 ivihcsagtg rtgcyivldv mldmaecegv vdiyncvktl csrrvnmiqt eeqyifihda 1141 ileaclcget tipvsefkat ykemiridpq snssqlreef qtlnsvtppl dveecsiall 1201 prnrdknrsm dvlppdrclp flistdgdsn nyinaaltds ytrsaafivt lhplqsttpd 1261 fwrlvydygc tsivmlnqln qsnsawpclq ywpepgrqqy glmevefmsg tadedlvarv 1321 frvqnisrlq eghllvrhfq flrwsayrdt pdskkaflhl laevdkwqae sgdgrtivhc 1381 lngggrsgtf cacatvlemi rchnlvdvff aaktlrnykp nmvetmdqyh fcydvaleyl 1441 eglesr // Revised: July 5, 2002. 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