BatVI
BatVI

BatVI is a fast and sensitive method to determine viral integrations. We have benchmarked BatVI with existing methods and the results are given below. BatVI is freely available.

Sensitivity

We have tested the programs BatVI, ViruSeq and VFinder on Liver cancer datasets for HBV integration. HIVID is a highly sensitive protocol to get accurate viral integration sites. We treat HIVID as a golden dataset. As can be seen in the Venn diagram below, BatVI was able to detect most of the viral integrations given by HIVID.

Speed

We have tested BatVI, VirusSeq and VirusFinder on several sampled NGS datasets. The timings (in seconds) given below show that BatVI is the fastest method.
VirusSeqVfinderBatVI
145T.170139063.0910681.891068.59
145T.800142839.849708.241818.19
174T.170138189.38404.97347.36
174T.800174110.811255.71895.41
182T.170138965.8910423.38397.17
182T.800143127.6212803.67321.79
186T.170119893.7910519.19221.69
186T.800121806.5111444.95220.89
23T.170118660.110662.88457.6
23T.800116794.811226.1517.36
266T.170118169.5910419.9344.68
266T.80096608.799852.84240.1
32T.170178890.789734.77271.37
32T.800139353.668969.77231.51