NCBI Sequence Viewer PubMedNucleotideProteinGenomeStructurePMCTaxonomyOMIMBooks Search PubMed Protein Nucleotide Structure Genome PMC OMIM Taxonomy Books ProbeSet 3D Domains UniSTS Domains SNP Journals UniGene PopSet for Limits Preview/Index History Clipboard Details Summary ASN.1 FASTA TinySeq XML GenBank GBSeq XML GI List Graphics XML defaultShow: 1 2 5 10 20 50 100 200 500 File Text Clipboard 1: NM_005704. Homo sapiens prot...[gi:19743934] Links LOCUS PTPRU 5637 bp mRNA linear PRI 17-JAN-2003 DEFINITION Homo sapiens protein tyrosine phosphatase, receptor type, U (PTPRU), transcript variant 3, mRNA. ACCESSION NM_005704 VERSION NM_005704.2 GI:19743934 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5637) AUTHORS Wang,H., Lian,Z., Lerch,M.M., Chen,Z., Xie,W. and Ullrich,A. TITLE Characterization of PCP-2, a novel receptor protein tyrosine phosphatase of the MAM domain family JOURNAL Oncogene 12 (12), 2555-2562 (1996) MEDLINE 96293401 PUBMED 8700514 REFERENCE 2 (bases 1 to 5637) AUTHORS Crossland,S., Smith,P.D. and Crompton,M.R. TITLE Molecular cloning and characterization of PTP pi, a novel receptor-like protein-tyrosine phosphatase JOURNAL Biochem. J. 319 (Pt 1), 249-254 (1996) MEDLINE 97024447 PUBMED 8870675 REFERENCE 3 (bases 1 to 5637) AUTHORS Wang,B., Kishihara,K., Zhang,D., Hara,H. and Nomoto,K. TITLE Molecular cloning and characterization of a novel human receptor protein tyrosine phosphatase gene, hPTP-J: down-regulation of gene expression by PMA and calcium ionophore in Jurkat T lymphoma cells JOURNAL Biochem. Biophys. Res. Commun. 231 (1), 77-81 (1997) MEDLINE 97223402 PUBMED 9070223 REFERENCE 4 (bases 1 to 5637) AUTHORS Avraham,S., London,R., Tulloch,G.A., Ellis,M., Fu,Y., Jiang,S., White,R.A., Painter,C., Steinberger,A.A. and Avraham,H. TITLE Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells JOURNAL Gene 204 (1-2), 5-16 (1997) MEDLINE 98094249 PUBMED 9434160 REFERENCE 5 (bases 1 to 5637) AUTHORS Wang,B., Kishihara,K., Zhang,D., Sakamoto,T. and Nomoto,K. TITLE Transcriptional regulation of a receptor protein tyrosine phosphatase gene hPTP-J by PKC-mediated signaling pathways in Jurkat and Molt-4 T lymphoma cells JOURNAL Biochim. Biophys. Acta 1450 (3), 331-340 (1999) MEDLINE 99326162 PUBMED 10395944 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X97198.1 and X95712.1. On Mar 26, 2002 this sequence version replaced gi:5032002. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported. Transcript Variant: This variant (3) encodes the longest isoform (3). COMPLETENESS: complete on the 3' end. FEATURES Location/Qualifiers source 1..5637 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1p35.3-p35.1" gene 1..5637 /gene="PTPRU" /note="synonyms: OF, FMI, PTP, PCP-2, PTP-J, PTPRO, PTPU2, GLEPP1, PTP-PI, PTPPSI, hPTP-J, R-PTP-PSI, pi R-PTP-Psi" /db_xref="LocusID:10076" /db_xref="MIM:602454" CDS 137..4477 /gene="PTPRU" /note="protein tyrosine phosphatase, receptor type, U; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron" /codon_start=1 /product="protein tyrosine phosphatase, receptor type, U isoform 3 precursor" /protein_id="NP_005695.2" /db_xref="GI:19743935" /db_xref="LocusID:10076" /db_xref="MIM:602454" /translation="MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQA QYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQF SYFLYSRDGHRPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQV LFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAM RQRFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSN FAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEV HAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAF AEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWE EPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFS VRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISV YQVIVEEERARRLRRERGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTV GDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQ RSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQE KTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRR PCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKV KGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDF WRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTF ALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAG TGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL CGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNR DKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFW RLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIV HCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVA LEYLEGLESR" sig_peptide 137..190 /gene="PTPRU" mat_peptide 191..4474 /gene="PTPRU" /product="protein tyrosine phosphatase, receptor type, U, isoform 3" misc_feature 200..700 /gene="PTPRU" /note="MAM; Region: Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)" /db_xref="CDD:smart00137" misc_feature 215..700 /gene="PTPRU" /note="MAM; Region: MAM domain. An extracellular domain found in many receptors" /db_xref="CDD:pfam00629" misc_feature 722..985 /gene="PTPRU" /note="IG; Region: Immunoglobulin" /db_xref="CDD:smart00409" misc_feature 992..1207 /gene="PTPRU" /note="FN3; Region: Fibronectin type 3 domain" /db_xref="CDD:smart00060" misc_feature 1010..1207 /gene="PTPRU" /note="fn3; Region: Fibronectin type III domain" /db_xref="CDD:pfam00041" misc_feature 1292..1549 /gene="PTPRU" /note="FN3; Region: Fibronectin type 3 domain" /db_xref="CDD:smart00060" misc_feature 1586..1864 /gene="PTPRU" /note="FN3; Region: Fibronectin type 3 domain" /db_xref="CDD:smart00060" misc_feature 1592..1870 /gene="PTPRU" /note="fn3; Region: Fibronectin type III domain" /db_xref="CDD:pfam00041" misc_feature 2813..3574 /gene="PTPRU" /note="PTPc; Region: Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" misc_feature 2822..3049 /gene="PTPRU" /note="AceE; Region: Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]" /db_xref="CDD:COG2609" misc_feature 2888..3565 /gene="PTPRU" /note="Y_phosphatase; Region: Protein-tyrosine phosphatase" /db_xref="CDD:pfam00102" misc_feature 2909..3565 /gene="PTPRU" /note="PTP2; Region: Protein tyrosine phosphatase [Signal transduction mechanisms]" /db_xref="CDD:COG5599" misc_feature 3260..3565 /gene="PTPRU" /note="PTPc_motif; Region: Protein tyrosine phosphatase, catalytic domain motif" /db_xref="CDD:smart00404" misc_feature 3287..3550 /gene="PTPRU" /note="CDC14; Region: Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]" /db_xref="CDD:COG2453" misc_feature 3593..4459 /gene="PTPRU" /note="PTP2; Region: Protein tyrosine phosphatase [Signal transduction mechanisms]" /db_xref="CDD:COG5599" misc_feature 3659..4459 /gene="PTPRU" /note="PTPc; Region: Protein tyrosine phosphatase, catalytic domain" /db_xref="CDD:smart00194" misc_feature 3743..4450 /gene="PTPRU" /note="Y_phosphatase; Region: Protein-tyrosine phosphatase" /db_xref="CDD:pfam00102" misc_feature 4142..4450 /gene="PTPRU" /note="PTPc_motif; Region: Protein tyrosine phosphatase, catalytic domain motif" /db_xref="CDD:smart00404" variation 847 /gene="PTPRU" /allele="T" /allele="G" /db_xref="dbSNP:1128404" variation 2058 /gene="PTPRU" /allele="G" /allele="C" /db_xref="dbSNP:1045451" variation 2731 /gene="PTPRU" /allele="T" /allele="C" /db_xref="dbSNP:2295061" variation 3198 /gene="PTPRU" /allele="C" /allele="A" /db_xref="dbSNP:2235940" variation 3748 /gene="PTPRU" /allele="T" /allele="C" /db_xref="dbSNP:1045453" variation 4979 /gene="PTPRU" /allele="T" /allele="A" /db_xref="dbSNP:1062921" polyA_signal 5593..5598 /gene="PTPRU" polyA_site 5615 /gene="PTPRU" BASE COUNT 1120 a 1797 c 1660 g 1060 t ORIGIN 1 aattccgggc gccagtcccg ctccgcgccg cgccgctccg ctccggctcg ggctccggct 61 cgcctcgggc tgggctcggg ctccgggggc ggcgtccccg ccgccgggcc ccgggacggg 121 cggcgacgct ccaaccatgg cccgtgccca ggcgctcgtg ctggcactca ccttccagct 181 ctgcgcgccg gagaccgaga ctccggcagc tggctgcacc ttcgaggagg caagtgaccc 241 agcagtgccc tgcgagtaca gccaggccca gtacgatgac ttccagtggg agcaagtgcg 301 aatccaccct ggcacccggg cacctgcgga cctgccccac ggctcctact tgatggtcaa 361 cacttcccag catgccccag gccagcgagc ccatgtcatc ttccagagcc tgagcgagaa 421 tgatacccac tgtgtgcagt tcagctactt cctgtacagc cgggacgggc acaggccggg 481 caccctgggc gtctacgtgc gcgttaatgg gggccccctg ggcagtgctg tgtggaatat 541 gactggatcc cacggccgtc agtggcacca ggctgagctg gctgtcagca ctttctggcc 601 caatgaatat caggtgctgt ttgaggccct catctcccca gaccgcaggg gctacatggg 661 cctagatgac atcctgcttc tcagctaccc ctgcgcaaag gccccacact tctcccgcct 721 gggcgacgtg gaggtcaacg cgggccagaa cgcgtcgttc cagtgcatgg ccgcgggcag 781 agcggccatg cgccaacgct tcctcttgca acggcagagc ggggccctgg tgccggcggc 841 gggcgttcgg cacatcagcc accggcgctt cctggccact ttcccgctgg ctgccgtgag 901 ccgcgccgag caggacctgt accgctgtgt gtcccaggcc ccgcgcggcg cgggcgtctc 961 taacttcgcg gagctcatcg tcaaggagcc cccaactccc atcgcgcccc cacagctgct 1021 gcgtgctggc cccacctacc tcatcatcca gctcaacacc aactccatca ttggcgacgg 1081 gccgatcgtg cgcaaggaga ttgagtaccg catggcgcgc gggccctggg ctgaggtgca 1141 cgccgtcagc ctgcagacct acaagctgtg gcacctcgac cccgacacag agtatgagat 1201 cagcgtgctg ctcacgcgtc ccggagacgg cggcactggc cgccctgggc cacccctcat 1261 cagccgcacc aaatgcgcag agcccatgag ggcccccaaa ggcctggctt ttgctgagat 1321 ccaggcccgt cagctgaccc tgcagtggga accactgggc tacaacgtga cgcgttgcca 1381 cacctatact gtgtcgctgt gctatcacta caccctgggc agcagccaca accagaccat 1441 ccgagagtgt gtgaagacag agcaaggtgt cagccgctac accatcaaga acctgctgcc 1501 ctatcggaac gttcacgtga ggcttgtcct cactaaccct gaggggcgca aagagggcaa 1561 ggaggtcact ttccagacgg atgaggatgt gcccagtggg attgcagccg agtccctgac 1621 cttcactcca ctggaggaca tgatcttcct caagtgggag gagccccagg agcccaatgg 1681 tctcatcacc cagtatgaga tcagctacca gagcatcgag tcatcagacc cggcagtgaa 1741 cgtgccaggc ccacgacgta ccatctccaa gctccgcaat gagacctacc atgtcttctc 1801 caacctgcac ccaggcacca cctacctgtt ctccgtgcgg gcccgcacag gcaaaggctt 1861 cggccaggcg gcactcactg agataaccac taacatctct gctcccagct ttgattatgc 1921 cgacatgccg tcacccctgg gcgagtctga gaacaccatc accgtgctgc tgaggccggc 1981 acagggccgc ggtgcgccca tcagtgtgta ccaggtgatt gtggaggagg agcgggcgcg 2041 gaggctgcgg cgggagcgag gtggacagga ctgcttccca gtgccattga ccttcgaggc 2101 ggcgctggcc cgaggcctgg tgcactactt cggggccgaa ctggcggcca gcagtctacc 2161 tgaggccatg ccctttaccg tgggtgacaa ccagacctac cgaggcttct ggaacccacc 2221 acttgagcct aggaaggcct atctcatcta cttccaggca gcaagccacc tgaaggggga 2281 gacccggctg aattgcatcc gcattgccag gaaagctgcc tgcaaggaaa gcaagcggcc 2341 cctggaggtg tcccagagat cggaggagat ggggcttatc ctgggcatct gtgcaggggg 2401 gcttgctgtc ctcatccttc tcctgggtgc catcattgtc atcatccgca aagggagaga 2461 ccactatgcc tactcctact acccgaagcc ggtgaacatg accaaggcca ccgtcaacta 2521 ccgccaggag aagacacaca tgatgagcgc cgtggaccgc agcttcacag accagagcac 2581 cctgcaggag gacgagcggc tgggcctgtc cttcatggac acccatggct acagcacccg 2641 gggagaccag cgcagcggtg gggtcactga ggccagcagc ctcctggggg gctccccgag 2701 gcgtccctgt ggccggaagg gctccccata ccacacgggg cagctgcacc ctgcggtgcg 2761 tgtcgcagac cttctgcagc acatcaacca gatgaagacg gccgagggtt acggcttcaa 2821 gcaggagtat gagagcttct ttgaaggctg ggacgccaca aagaagaaag acaaggtcaa 2881 gggcagccgg caggagccaa tgcctgccta tgatcggcac cgagtgaaac tgcacccgat 2941 gctgggagac cccaatgccg actacattaa tgccaactac atagatggtt accacaggtc 3001 aaaccacttc atagccactc aagggccgaa gcctgagatg gtctatgact tctggcgtat 3061 ggtgtggcag gagcactgtt ccagcatcgt catgatcacc aagctggtcg aggtgggcag 3121 ggtgaaatgc tcacggtact ggccggagga ctcagacacc tacggggaca tcaagattat 3181 gctggtgaag acagagaccc tggctgagta tgtcgtgcgc acttttgccc tggagcggag 3241 aggctactct gcccggcacg aggtccgcca gttccacttc acagcgtggc cagagcatgg 3301 cgtcccctac catgccacgg ggctgctggc tttcatccgg cgcgtgaagg cctccacccc 3361 acctgatgcc gggcccattg tcatccactg cagcgcgggc accggccgca caggttgcta 3421 tatcgtcctg gatgtgatgc tggacatggc agagtgtgag ggcgtcgtgg acatttacaa 3481 ctgtgtgaag actctctgct cccggcgtgt caacatgatc cagactgagg agcagtacat 3541 cttcattcat gatgcaatcc tggaggcctg cctgtgtggg gagaccacca tccctgtcag 3601 tgagttcaag gccacctaca aggagatgat ccgcattgat cctcagagta attcctccca 3661 gctgcgggaa gagttccaga cgctgaactc ggtcaccccg ccgctggacg tggaggagtg 3721 cagcatcgcc ctgttgcccc ggaaccgcga caagaaccgc agcatggacg tcctgccgcc 3781 cgaccgctgc ctgcccttcc tcatctccac tgatggggac tccaacaact acattaatgc 3841 agccctgact gacagctaca cacggagtgc ggccttcatc gtgaccctgc acccgctgca 3901 gagcaccacg cccgacttct ggcggctggt ctacgattac gggtgcacct ccatcgtcat 3961 gctcaaccag ctgaaccagt ccaactccgc ctggccctgc ctgcagtact ggccagagcc 4021 aggccggcag caatatggcc tcatggaggt ggagtttatg tcgggcacag ctgatgaaga 4081 cttagtggct cgagtcttcc gggtgcagaa catctctcgg ttgcaggagg ggcacctgct 4141 ggtgcggcac ttccagttcc tgcgctggtc tgcataccgg gacacacctg actccaagaa 4201 ggccttcttg cacctgctgg ctgaggtgga caagtggcag gccgagagtg gggatgggcg 4261 caccatcgtg cactgcctaa acgggggagg acgcagcggc accttctgcg cctgcgccac 4321 ggtcctggag atgatccgct gccacaactt ggtggacgtt ttctttgctg ccaaaaccct 4381 ccggaactac aaacccaaca tggtggagac catggatcag taccactttt gctacgatgt 4441 ggccctggag tacttggagg ggctggagtc aagatagcgg ggccctggcc tggggcaccc 4501 actgcacact cagggccaga cccaccatcc tggactggcg aggaagatca gtgcctcctg 4561 ctctgcccaa acacactccc atggggcaag cactggagtg gatgctgggc tatcttgctc 4621 ccccttccac tgtgggcagg gcctttcgct tgtcccatgg gcgggtggtg ggccaaggag 4681 gagcttagca agtctgcagc ccagccccac ctccataggg tcctgcaggc ctgtgctgag 4741 aggcctggtg ctgcctggca gagtgacaaa ggctcaggac ggctggctct gggggactca 4801 ggccaagccc cttggcacca tcctggcttt tggcagggat gagtgaggcc ctgcagagag 4861 catcccaggc caaggttccc actcagcctg ccccctctgc atgtgggtag aggatgtact 4921 gggacttggc atttaggatt ccatctggcc cagcccctga aggtcctggg gaagcaggtc 4981 tcaattctga atagccagtg gggcacactg actgtcctcc ccaggggaac tgcagcgccc 5041 tcctccccac tgccccctgc agcccctgag atattttgct cactatccct ccccacttgc 5101 ttccctgata tgtgctctga gcttccctga accaggatct gcctattact gctgtgcccc 5161 atggggggct ccttccctgc ctgacccact gttgcagaat gaagtcacct cgcccccctc 5221 ttcctttaat cttcaggcct cactggcctg tcctgctcag cttgggccag tgacaatctg 5281 caaggctgaa caacagcccc tggggttgag gcccctgtgg ctcctggtca ggctgcccgt 5341 tgtggggagg ggcagtgtta gagcagggct ggtcataccc tctggagttc agaggaagag 5401 gtaggaccag tgcttttttg tttcttttgt tatttttggt tgggtgggtg ggaaggtctc 5461 tttaaaatgg ggcaggccac acccccattc cgtgcctcaa tttccccatc tgtaaactgt 5521 agatatgact actgacctac ctcgcagggg gctgtgggga ggcataagct gatgtttgta 5581 aagcgctttg taaataaacg tgctctctga atgccaaaaa aaaaaaaaaa aaaaaaa // Revised: July 5, 2002. 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