Peptide-Binding Prediction Results

• We have tested our MHC-peptide binding models on Melanoma, IDDM, and malaria parasites with very promising results

• The experiments:

  study MHC molecule no. of antigens peptide pool

  IDDM DR4 1 68

  Melanoma DR4 4 1374

  Malaria A11 6 3000

• The results:

  study no. of peptides exp. binders true pos false pos exp. epitopes true pos

  IDDM 68 22 17 10 17 12

  Melanoma* 30 - - - 18 18

  Malaria* 37 10 10 26 10 10

  * only predicted epitopes were tested